Metabolic Classrooms

The Metabolic Classroom is a science-based video series hosted by Dr. Benjamin Bikman, a leading expert on insulin resistance and metabolic health. Each episode breaks down complex research into simple, practical lessons about how your body uses energy, burns fat, and maintains long-term health. Learn how insulin, hormones, and nutrition influence everything from weight loss to chronic disease prevention—so you can take control of your metabolic health with real science that makes sense.

Ketones and the Heart: Why Your Cardiovascular System Thrives on This “Fasting Fuel”

Ketones are often seen as backup fuel, but the heart tells a different story. In this article and full lecture, Dr. Ben Bikman explains how ketones support the cardiovascular system as high-octane fuel, reduce the heart’s workload, calm inflammation, protect against oxidative stress, and improve vascular function. When we look at the biochemistry and physiology—not the diet debates—ketones emerge as powerful allies for heart health.

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Sex Differences in Ketogenesis: How Hormones Shape Fat Metabolism and Ketone Production

Men and women display distinct patterns in fat metabolism and ketone production, driven by hormonal, enzymatic, and adipose-tissue differences. Estrogen enhances fat mobilization and hepatic ketogenesis, while testosterone favors glycolytic pathways. Recognizing these sex-based distinctions refines how we interpret metabolic data and design nutrition strategies in research and clinical settings.

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The Metabolic Storm of Concussions: How Ketones Protect the Injured Brain

A concussion triggers a metabolic storm inside the brain—disrupting glucose use, impairing mitochondria, and creating oxidative stress. But ketones offer a powerful metabolic alternative: they supply energy efficiently, reduce inflammation, and support recovery at the cellular level. This post explores the mechanisms behind concussion-related energy failure and the emerging evidence on how ketogenic metabolism enhances neuroprotection and healing.

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